On Friday, November 16, 2018, the Collaborative for Research on Acute Neurological Injuries (CRANI) was pleased to host speaker Peter Margolis, MD, PhD, a pioneer in the Learning Health Systems approach to clinical care and research. Traditional concepts of research – from bench to phased trials to clinical care – are often inefficient and do not address existing practical clinical problems. Acute brain injuries in particular create unique challenges both for researchers and clinicians. Attendees learned about the development of Learning Health Systems, a networked model of outcomes-based research that allows for flexibility and efficiency in hypothesis testing in order to accelerate the pace of clinical and translational research insights.